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Pharmaceutical Benefits 2005 2006 Wayne Creech, R. Ph. Martha Jones, Pharm. D. Thomas Thutt, R.Ph. Gina Upchurch, R.Ph., M.P.H. New Brand Name Products Contact. Single-inhalation combination therapy At present, only one product offering an ICS and a long-acting beta2-agonist LABA ; via a single inhaler is available in the United States -- the combination of fluticasone and salmeterol Arvair ; , a top-selling drug in the United States. This fluticasone salmeterol combination product reviewed in detail by Kavuru, beginning on page 28 ; is supplied as a fixed 50 mcg dose of salmeterol together with 1 of 3 doses of fluticasone: 100, 250, or 500 mcg. Hence, increasing or decreasing the daily dose of fluticasone necessitates switching to a different inhaler. Internationally, Advari is marketed as Seretide, which competes with another ICS LABA combination provided in a single inhaler, budesonide and formoterol. In contrast to salmeterol, formoterol is a rapid-acting LABA. In Europe, formoterol is used as a rescue medication, owing to its rapid onset of action, 1 to 3 minutes, which is comparable to that of salbutamol albuterol ; . In a large N 18, 124 ; open-label international study, formoterol was shown to have a safety profile similar to that of salbutamol Pauwels 2003 ; . This study enrolled patients ranging in age from 4 to 91 years, with asthma of all degrees of severity, using a wide range of maintenance therapies. In addition to being used as maintenance therapy, budesonide formoterol is being investigated for use in providing acute relief. In a double-blind 1-year study, 2, 760 patients with asthma were randomized to 1 of regimens: budesonide 80 mcg formoterol 4.5 mcg twice daily, plus the same formulation as needed for relief; budesonide 80 mcg formoterol 4.5 mcg twice daily, plus terbutaline 0.4 mcg as needed; or budesonide 320 mcg plus terbutaline 0.4 mcg as needed O'Byrne 2005 ; . Patients ranged in age from 4 to 80 years, and their FEV1 at baseline ranged between 60 and 100 percent of predicted. In the group using budesonide formoterol for both maintenance and relief, the risk of severe exacerbation was 45 percent lower than that in the budesonide formoterol-plusterbutaline group and 47 percent lower than that in the high-dose budesonide-plus-terbutaline group. Severe exacerbation was defined as hospitalization or an emergency department visit, treatment with oral steroids, or morning peak expiratory flow less than or equal to 70 percent of baseline on 2 consecutive days. ; Rates of adverse events were similar among all treatment groups. 23865 Maharat Nakhonratchasima hospital Suttinee Ruangsupunth. Epidemiology and problems in the treatment of melioidosis in Maharat Nakhonratchasima hospital. Khon Kaen : Khon Kaen University, 2002. 76 p. T E18754 ; Maharat Nakorn Si Thammarat hospital Samarnsri Komsamarn. Determinants of pneumonia in children under five years old at Maharat Nakorn Si Thammarat hospital. Bangkok : Mahidol University, 2001. 74 p. T E17573 ; Mahasarakham University--Students : , 2542. 86 . 100373 ; Mahayana Buddhism Olson, Grant. Sangha reform in Thailand : limitation, liberation and the middle path. Hawaii : University of Hawaii, 1983. 3 138 ; . T MF12326 ; Mahidal University. Department of Technology of Information System Management--Students Surasak Komolmatha. Web application and student management system : a case study in a branch of the Graduate Office, Faculty of Engineering, Mahidol University. Bangkok : Mahidol University, 2001. 55 p. T E16625 ; Mahidol University Saisuda Boonwiset. Factors influencing the potential decisions of government officials to become state employees under an autonomous university : a case study of Mahidol University. Bangkok : Mahidol University, 2002. 103 p. T E18053 ; Mahidol University--Administration Schorghuber, Ingrid. Stress, stress' coping behavior and other psychosocial factors among the 1992 foreign postgraduate students, and its impact on the administrational structure of Mahidol University. Bangkok : Mahidol University, 1993. viii, 105 p. T E7832 ; Mahidol University--Curricula Wiwat Puntai. An Evaluation of the M.A. courses in applied linguistics at Mahidol University 1981-1984. Bangkok : Mahidol University, 1986. 3 microfiches 145 fr. ; . T MF20292 ; Mahidol University--Dissertations Nguyen, Cong Khanh. Critical review of master of primary health care management's theses, AIHD, Mahidol University, 1998-2000. Bangkok : Mahidol University, 2002. 100 p. T E17659. 7 0 comment advair - pricey but convenient cost is becoming a big issue for me with this medication and aldactone. Significant recordkeeping and reporting burdens are lifted when the new drug status terminates.
Important information about ADVAIR. ADVAIR won't replace fast-acting inhalers for sudden symptoms and should not be taken more than twice a day. Rare but serious asthma episodes and asthma-related fatalities occurred in a study with SEREVENT, one of the components of ADVAIR. While adjusting to a switch from an oral steroid, like prednisone, to the inhaled steroid in ADVAIR, be very careful, as you may be less able to heal after surgery, infection, or serious injury. Tell your doctor if you have a heart condition or high blood pressure. Some people may experience increased blood pressure, heart rate, or changes in heart rhythm. See your doctor if your asthma does not improve. ADVAIR is for patients 4 years and older. For patients 4 to 11 years old, ADVAIR 100 50 is for those who have asthma symptoms while on an inhaled corticosteroid and aldara. Hepatitis C is transmitted through blood. The sharing of drug injecting equipment is the most common route if transmission in the UK. Many people also contracted hepatitis C from blood products before screening and sterilisation was introduced.
I on rhinocort nasal steroid ; and advair for 6 weeks now to try to decrease the inflammation and alendronate.
Advair 25050 diskus 26 tue 2007 : 17 utc advair disk inhaler : problem solversymptom checkermedical adviceasthmacoughasthma in advair, serevent, and black patients if lipitor and older and older, see individual risks or 3, 520 mcg and loads a lawyer mesothelioma mirapex natrecor fails efficacy and a giant trial. The responses from the risk and obstetric professionals, outlined in Sections 1.1 and 1.2, identified strong support for further investigation into risk perceptions toward technology throughout the NHS. Three potential areas for further work are described below. These include: the association between risk perceptions and technological training; how risk perception can be integrated into current technology risk assessment; and, the relationship between risk communication and the introduction of new technologies in healthcare. 3.1 Perception Training and amlodipine. A B Otic.9 Accu-Chek Active .16 Accu-Chek Advantage Glucometer .16 Accu-Chek Advantage Test Strips.16 Accu-Chek Aviva .16 Accu-Chek Comfort Test Strips.16 Accu-Chek Compact.16 Acetaminophen W CodeineQL .8 Actonel .10 Acyclovir .6 Advalr Diskus .14 Agenerase .6 Aggrenox .12 Albuterol.14 Albuterol Sulfate.14 Allopurinol.12 Amantadine.6 Amaryl.10 Amcinonide .9 Amiloride HCL W HCTZ.7 Amiodarone .7 Amox TR Potassium Clavulanate.5 Amox TR-K CLV 600 .5 Amoxicillin.5 Ana-Kit .14 Analpram-HC .11 Antabuse .8 Apri.13 Aptivus .6 Aranelle .13 Arimidex.6 Arixtra.12 Asacol .11 Ascensia Autodisc Blood Glucose Test Strips.16 Ascensia BREEZE.16 Ascensia CONTOUR.16 Ascensia Microfill Blood Glucose Test Strips.16 Atenolol .7 Atenolol Chlorthalidone .7 Atrovent.14 Avandia.10 Aviane.13 Avonex Administration Pack.11 Azathioprine .6 Azithromycin .5. Pharmaceutical sales continue strong growth, up 10%: Growth especially strong in USA at 15%; Europe 4%; Rest of World 7% Strong growth in key therapy areas: CNS 10%; Respiratory 25%, Anti-virals 17% New products up 58%, now represent 25% of sales Seretide Dvair is already GSK's third largest product after less than one year on the US market In-licensing programme delivers two new deals, including alvimopan in phase III for bowel dysfunctions following surgery Business performance EPS growth of 18%, reflecting sales growth and merger cost savings. The company is on track to meet 2002 business performance EPS growth in the mid-teens and amoxycillin. Helpful medications include h2 receptor antagonists or h2 blockers ; and proton pump inhibitors, which reduce the amount of acid produced by the stomach, for example, alternative to advair.

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Discussion This study provides several new pieces of information on the role of receptor status in breast cancer. First, although previous epidemiologic studies have produced inconsistent data on the relationship between ER status and risk factors, the joint stratification on estrogen and progestrogen receptors produces a somewhat more interpretable as well as intriguing pattern. Second, the appearance of differences in patterns of association between receptor-defined subtypes and specific known risk factors for breast cancer, plus the data suggesting tumor size differences across subtypes do not explain these patterns, provide some answer to the question of whether the receptor profile of a particular breast cancer is evidence of discrete tumor types or merely a marker modifiable over time ; of the degree of malignant behavior. Third, some of the specific associations suggest new directions for study. Before expanding on these points, it is appropriate to consider the quality of the outcome data. Receptor status was established at a variety of clinical laboratories rather than at a single reference laboratory. There are, nonetheless, two reasons to argue for the usefulness of the data: a ; the methodology for establishing receptor status has become increasingly routine and standardized 7 ; and b ; empirical observation that the distribution of ER PR status seen in Table 1 essentially is identical to that seen in the reference laboratory studies. For example, Thorpe 7 ; reported a distribution in postmenopausal women for ER + PR PR-, ER-PR + , and ER-PRof 64%, 17%, 3%, and 16%, respectively. The proportions from Bland et a!. 34 ; were 63%, 15%, 5%, and 17%, respectively. These compare with the distribution among those with known receptor status in the population described here of 69%, 15%, 3%, and 13%, respectively. Of course, similarity of distributions still is compatible with some random misclassification. Three important patterns suggest themselves: the PR + , the ER + PR-, and ER-PR. The PR + pattern is associated with family history and with variables that may be characterized as those related to endogenous hormone exposure, body mass, body fat distribution, age at menarche, and age at first birth and perhaps parity ; . It previously has been thought that the associations, particularly with the "classic" reproductive variables and clavulanate. It' s worked wonders and i have only needed my rescue inhaler once - because i had used my advair disc when it was empty thinking it wasn' t.

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He also takes theophylline er 200mg twice a day and has a rx for a rescue inhaler which he has not used since starting on advair and ampicillin. This emedtv article describes advair in more detail and lists conditions to tell your doctor about before taking the drug.
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17.1 Antacids and other antiulcer medicines aluminium hydroxide tablet, 500 mg; oral suspension, 320 mg 5 ml and anastrozole.
Sibelium flunarizine ; calcium channel blocker seretide accuhaler advair diskus , salmeterol , fluticasone ; advair fluticasone and salmeterol ; is a combination controller medicine for long-term treatment to prevent or decrease the symptoms of asthma and chronic lung diseases such as emphysema, bronchitis, or copd. COMPANY agrees to reimburse PFIZER for its out of pocket costs per batch prorated over the usable portion of the batch if applicable, for any loss of PFIZER supplied i ; Raw Materials; ii ; API; or iii ; Packaging Materials for each batch that does not meet Specifications and therefore cannot be released, provided that the loss of such Raw Materials, API or Packaging Materials was caused by, a ; the failure of COMPANY to comply with the terms and conditions of the Agreement including, without limiting the foregoing, the failure to meet the Specifications b ; the negligence of COMPANY; c ; willful misconduct on the part of COMPANY; d ; failure to maintain the Facilities or equipment in a state necessary and capable of performing COMPANY's obligations under this Agreement; or e ; unable to meet minimum established yields as specified in the Addendum. In addition to this payment, COMPANY will be responsible for all manufacturing costs incurred during the manufacture of the failed batch, pro-rated over the usable portion of the batch if applicable. COMPANY shall not be responsible for the above costs if loss of Raw Materials, API or Packaging Materials was caused by incorrect Specifications given to COMPANY by PFIZER or as a result of PFIZER's delay to grant consent to changes sought in accordance with Section 5.2. SECTION 12. CONFIDENTIAL INFORMATION. 12.1 Confidential Information and arava and advair, for example, beyond advair.

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1. History of anaphylactic reaction and similarly severe significant hypersensitivity to medication prescribed or structurally related medication. 2. Severe CNS depression 3. QTc 450 msec 4. Hypomagnesemia Absolute Contraindications Relative 5. Hypokalemia 6. Retinitis Pigmentosa 7. Concomitant use of other drugs known to prolong QTc interval 8. Known heart disease 9. Personal history of syncope 10. Family history of sudden death at an early age under age of 40 years ; 11. Congenital long QT syndrome 1. Pregnancy nursing mothers 2. History of drug induced agranulocytosis or leukopenia 3. Breast cancer 4. History of neuroleptic malignant syndrome 5. Narrow angle glaucoma 6. Impaired hepatic function 7. Prostatic hypertrophy 8. Parkinson's disease.
A ABILIFY . 17 ACCOLATE . 25 ACCUPRIL . 22 Acebutolol HCL. 10 acetaminophen - codeine elixir. 6 acetaminophen - codeine tablets . 6 Acetazolamide . 10 ACIPHEX . 24 ACTONEL. 19 ACTOS. 17 ACULAR . 25 ACULAR LS . 25 Acyclovir . 9 ADALAT CC . 22 ADDERALL XR . 23 ADVAIR DISKUS . 20 ADVICOR . 22 Afeditab CR . 10 AGGRENOX . 22 albuterol inhaler, tablets, syrup. 14 ALLEGRA . 25 ALLEGRA-D 12 HOUR . 25 ALLEGRA-D 24 HOUR . 25 Allopurinol . 8 ALPHAGAN P . 20 ALTACE . 18 ALTOPREV . 22 Amantadine . 9 AMARYL . 22 AMBIEN . 20 Amiloride HCL w HCTZ . 10 Amiodarone HCL . 10 Amitriptyline HCL. 8 Amitriptyline w perphenazine . 9 Amoxicillin . 7 Amoxil . 7 ANDROGEL . 19 ARANESP * . 26 ARICEPT. 16 ARIMIDEX . 24 ARMOUR THYROID . 24 ARTHROTEC . 21 ASACOL . 19 ASTELIN . 20 ATACAND . 22 ATACAND HCT . Atenolol. Atenolol w chlorthalidone . ATROVENT INHALER . AUGMENTIN XR. AVALIDE . AVANDAMET . AVANDIA . AVAPRO . AVELOX . AVODART . azathioprine * tablets . AZMACORT . AZOPT . B Baclofen . 15 BACTROBAN. 23 Belladonna w phenobarbital . 13 Benazepril HCL . 10 Benazepril HCL-HCTZ . 10 BENICAR . 18 BENICAR HCT . 18 Benztropine mesylate . 9 Betamethasone dipropionate . 12 betamethasone dp augmented . 12 Betaxolol HCL . 10 Bethanechol chloride . 13 BIAXIN . 16 BIAXIN XL . 16 Bisoprolol fumarate. 10 Bisoprolol fumarate HCTZ . 10 BONIVA . 24 Brimonidine tartrate . 14 budeprion SR, buproprion SR . 8 Bumetanide . 10 Bupropion HCL . 8 Buspirone HCL . 9 C CADUET . 22 Captopril . 10 Carbamazepine. 7 Carbidopa-levodopa . 9 CARDIZEM CD . 22 CARDIZEM LA . 22 and atarax. Thu september 20 2007 products by category allergy & asthma montelukast advajr diskus anti depression fluoxetine prozac ; , zoloft , celexa cipramil ; anafranil , effexor , lexapro cipralex ; duloxetine , paroxetine sertraline pain relief imitrex imigran ; , zomig zolmitriptan ; , codeine aspirin dolmen ; , codeine paracetamol , effervescent cod-efferalgan ; gelocatil codeine , analgilasa codeine caffeine ; , fiorinal , dolgesic codeine , termalgin frenadol dextromethorphan with chlorpheniramine ; , disdolen , naproxen celebrex celecoxib ; , fludeten , gelocatil codeine , sumatriptan women's health nolvadex-d tamoxifen ; , premarin estrogen ; , clomid clomiphene citrate ; , arimidex anastrozole ; , risedronate , alendronate muscle relaxants carisoprodol mio-relax ; , baclofen , lioresal flexeril , yurelax cyclobenzaprine ; relaxibys men's health viagra sildenafil citrate ; , propecia levitra , proscar , generic viagra - caverta generic cialis , dutasteride , finasteride sedatives buspirone buspar ; sleep doxylamine dormidina ; , diphenhydramine soñ oror ; , sonata , zopiclone weight loss reductil meridia ; xenical orlistat ; other neurontin gabapentin ; , nexium esomeprazole ; proviron , gonadotropin , pregnyl , catapres, clonidine , dextromethorphan romilar ; , topamax topiramate ; , lipitor , campral acamprosate ; , zyban , sinemet carbidopa levodopa ; ephedrine , clenbuterol , tamiflu , atomoxetine , leflunomide , atorvastatin , simvastatin , rosuvastatin , inderal , amlodipine bupropion your topamax prescription drugs without the need for prescription or a prior doctor consultation.
Lamictal. The patents on the active ingredient lamotrigine are not due to expire until 2008a in the USA 2009 by virtue of paediatric exclusivity ; and 2005b in Europe. Retrovir. Basic patents on the active ingredient zidovudine have expired. Patents covering pharmaceutical formulations containing zidovudine and their medical use are not due to expire until 2006 in the USA and in Europe. Epivir. The patents on the active ingredient lamivudine are not due to expire until 2009 in the USA and 2011b in Europe. Combivir. The patents on the specific combination of lamivudine and zidovudine are not due to expire until 2012 in the USA and 2013b in Europe. Valtrex. The patents on the active ingredient valaciclovir are not due to expire until 2009a in the USA and 2009b in Europe . Ziagen. The patents on the active ingredient abacavir are not due to expire until 2011a in the USA and 2014b in Europe. Zofran. The patents on the active ingredient ondansetron are not due to expire until 2005 in the USA and 2005b in Europe. Patents on use for emesis expire in 2006. GlaxoSmithKline has initiated legal action under these patents against generic manufacturers in the US. Seretide Advair. The patents on the specific combination of active ingredients salmeterol and fluticasone propionate are not due to expire until 2010 in the USA and 2013b in Europe Avandia. The patents on the active ingredient rosiglitazone maleate are not due to expire until 2015 in the USA and 2013b in Europe. Serevent. Patents on the active ingredient salmeterol xinafoate are not due to expire until 2005b in most of Europe 2008b in France and 2012b in Italy ; and until 2008 in the USA. In common with many other companies, GlaxoSmithKline is routinely engaged in legal disputes in defence of patent rights on its products see Note 30 to the Financial statements, `Legal Proceedings' ; Trade marks All of GlaxoSmithKline's pharmaceutical products are protected by registered trade marks in major markets. In general the same mark is used for a product in each market around the world, but there may be local variations, for example in the United States the trade mark Paxil is used instead of Seroxat and Xdvair is used instead of Seretide. Trade mark protection may generally be extended for as a long as the trade mark is used by renewing it when necessary. GlaxoSmithKline's trade marks on pharmaceutical products generally assume an increasing importance when the patent for that product has expired in a particular country and generic versions of the product become available. In the Consumer Healthcare business trade marks are particularly important, as the business is very brand orientated and many products do not have patent protection. GlaxoSmithKline is routinely engaged in legal disputes in defence of its trade mark rights, and takes action against companies found infringing versions of its products. Other recent advar diskus, fluticasone salmeterol discussions topic updated last by comments warnings over asthma meds sep 2 julie 27 new warnings for 3 asthma drugs aug '07 pags 7 two inhalers are better than one for common lun. Read this information carefully before you begin treatment. Read the information you get whenever you get more medicine. There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment. If you have any questions about TRI-LUMA try-LOOM-ah ; , ask your doctor. Only your doctor can determine if TRI-LUMA is right for you. What is the most important information I should know about TRI-LUMA Cream? Use of TRI-LUMA Cream in pregnant women may carry the chance of having birth defects in the baby. Tell your doctor if you are pregnant, may be pregnant, or plan to become pregnant. Your doctor will talk with you about the benefits and risks of using TRI-LUMA during pregnancy to help decide if the benefits for you are greater than the risks. You may decide to delay treatment until after your baby is born. If you become pregnant while taking TRI-LUMA Cream, tell your doctor right away. You should discuss the chances that your baby may be harmed. Using TRI-LUMA Cream early in pregnancy may be more likely to produce birth defects than using it later in pregnancy. What is TRI-LUMA Cream? TRI-LUMA try-LOOM-ah ; Cream is a medicine with three active components. You put TRI-LUMA Cream on your face to treat a skin condition called melasma. Melasma consists of dark hyperpigmented ; spots on facial skin, especially on the cheeks and forehead. This condition usually happens with hormone changes. TRI-LUMA Cream is for short-term and intermittent long-term treatment of moderate to severe melasma of the face, in the presence of measures for sun avoidance, including the use of sunscreens. TRI-LUMA Cream showed a significantly favorable safety profile for the long-term treatment of melasma, up to 6 months. Milder forms of melasma may not need treatment with medicine. Melasma can also be managed by staying out of the sun or by stopping the use of birth control methods that involve hormones. In clinical studies, after 8 weeks of treatment with TRI-LUMA Cream, most patients had improvements, with 42 26% ; out of 161 patients experiencing complete clearing of their melasma. In most patients treated with TRI-LUMA Cream, melasma came back after treatment was stopped. If the underlying causes of melasma, such as the use of certain birth control pills or too much exposure to sunlight, are not removed, melasma will come back when you stop treatment. In the long-term studies, patients were treated with TRI-LUMA Cream on and off, whenever their melasma comes back until it clears. About 300 patients used TRI-LUMA Cream intermittently not continuously ; for 180 days, and majority of the side If you are pregnant, think you are pregnant, plan to be pregnant or are nursing an infant, tell your doctor. Your doctor will decide with you whether the benefits in using TRI-LUMA Cream will be greater than the risks. If possible, delay treatment with TRI-LUMA Cream until after the baby is born. Tell your doctor about all the other medicines and skin products you use, including prescription and nonprescription medicines, cosmetics, and supplements. They may make your skin more sensitive to sunlight. How should I use TRI-LUMA Cream? TRI-LUMA Cream should be used as instructed by your doctor. To help you use the medicine correctly, follow these steps: Gently wash your face with a mild cleanser. Don't use a wash cloth to apply the cleanser, just your fingers. Rinse and pat your skin dry. Apply TRI-LUMA Cream at night, at least 30 minutes before bedtime. Put a small amount pea sized or 1 2 inch or less ; of TRI-LUMA Cream on your fingertip. Apply a thin coat onto the discolored spot s ; . Include about 1 2 inch of normal skin surrounding the affected area. After you have used the medicine for a while, you may find that you need slightly less to do the job. Rub the medicine lightly and uniformly into your skin. The medicine should become invisible almost at once. If you can still see it, you are using too much. Keep the medicine away from the corners of your nose, your mouth, eyes and open wounds. Spread it away from those areas when applying it. Do not use more TRI-LUMA Cream or apply it more often than recommended by your doctor. Too much TRI-LUMA Cream may irritate your skin, waste medicine, and won't give you faster or better results. Do not cover the treated area with anything after applying TRI-LUMA Cream. If your skin gets too irritated, stop using TRI-LUMA Cream, and let your doctor know. To help avoid skin dryness, you may use a moisturizer in the morning after you wash your face. You may also use a moisturizer and cosmetics during the day. Use a sunscreen of at least SPF 30 and a wide-brimmed hat over the treated areas. It requires only a small amount of sunlight to worsen melasma. Melasma can get worse even if you don't get sunburn. Only your doctor knows which other medicines may be helpful during treatment, and will tell you about them if needed. Do not use other medicines unless your doctor approves them. If you get sunburned, stop using TRI-LUMA Cream until your skin is healed, for example, advxir diskus 500. Acidosis alters the electrical activity of cardiac muscle, having marked effects on most of the membrane currents that have been studied Orchard & Kentish, 1990; Orchard & Cingolani, 1994 ; and hence on the configuration of the action potential e.g. Fry & Poole-Wilson, 1981; Kurachi, 1982 ; . However, the effect of acidosis on the action potential will not be the same in all regions of the heart, because of regional differences in the expression of the ion channels underlying the membrane currents Casis et al. 1998; Cheng et al. 1999 ; . Acidosis-induced changes in any current that is not uniformly distributed throughout the heart will result in non-uniform changes in action potential configuration. In addition the effect of acidosis can depend on local conditions. For example, the transient outward current Ito ; is unaffected by acidosis at normal resting potentials, but becomes larger during acidosis when the diastolic membrane potential is depolarised Hulme & Orchard, 2000 ; . Since some regions of the heart have a relatively positive diastolic membrane potential e.g. the sinoatrial SA ; and atrioventricular AV ; nodes ; , Ito will increase in response to acidosis only in those regions which express Ito and have a depolarised diastolic membrane potential. It appears likely, therefore, that regional variations in protein expression and, for example, diastolic potential will result in regional differences in the response of the action potential configuration to acidosis. The resulting dispersion of action potential configuration would be expected to alter the ECG and may underlie some of the arrhythmias which have been reported during and after acidosis Antzelevitch et al. 1994; Orchard & Cingolani, 1994 ; . However, the effect of acidosis on the ECG is unpredictable for a number of reasons. First, the effect of acidosis on Ito, and possibly on other currents, depends on the diastolic membrane potential e.g. Hulme & Orchard, 2000 ; , which and aldactone.
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