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To achieve a shrink prostate, a mixture of equal amount of the hormone-reducing drugs and the alpha blockers is typical to achieve the desired outcome. Ayn Rand, " 'Extremism, ' or the Art of Smearing, " p. 176 in Capitalism: The Unknown Ideal New York: Signet Books, 1967 ; . If s odd that Bird decides to discuss the term's connotation instead of its denotation. Semantically and conceptually, denotation is more fundamental to a term than connotation. See, e.g. Greg Pence, "Virtue Theory, " [essay 21 ; and Charles Pigden, "Naturalism, " [essay 37 ; in A Companion to Ethics, [Malden, MA: Blackwell Publishers, 19931, edited by Peter Singer. Douglas Rasmussen and Douglas Den Uyl, Liberty and Nature: An Aristotelian Defense o Liberal f Order, La Salle, IL: Open Court Press, 19911, p. 32. Douglas Den Uyl, 'The Right to Welfare and the Virtue of Charity, " pp. 205-6 in Altruism, [Cambridge, UK: Cambridge University Press, 19931, edited by Ellen Frankel Paul, Fred D. Miller, and Jeffrey Paul. Den Uyl mentions Nicomachean Ethics V. 11 with respect to justice; on charity and friendship, see Nicomachean Ethics IX.4-9. f Tibor Machan, H u m Rights and Human Liberties: A Radical Reconsideration o the American Political Tradition Chicago, IL: Nelson Hall, 1975 Individuals and 7 k i Rights, [La Salle, IL: Open Court Press, 1989 Classical Individualism: The Supreme Importance o Each Individual [New York: f Routledge, 1998 ; . See also "Recent Work in Ethical Egoism, " American Philosophical Quarterly, vol. 16 January 1979 ; . For egoism in Liberty a n d Nature see the discussion of flourishing in chapters 1 and 2, and the discussion of self-love and friendship in chapter 5. See also Douglas Rasmussen, "Perfectionism, " in The Encyclopedia o Applied Ethics [San Diego: Academic Press, 19971, edited by Ruth Chadwick; f and Rasmussen, "Human Flourishing and the Appeal to Human Nature, " in Human Flourishing, Cambridge, UK: Cambridge University Press, 1999 ; . See also note 4 and references cited in Den Uyl's article. Cf. David Kelley, "Life, Liberty, and Property, " Social Philosophy and Policy, vol. 1 119841, p. 115; Tibor Machan, Classical Individualism p. 164. Kelley, "Life, Liberty, and Property, " p. 109. f The locus classicus is J o Locke's discussion in his First Treatise o Government, 1.41-2. See also f f Ayn Rand, 'The Ethics of Emergencies, " ch. 4 in The Virtue o Sel shness: A New Concept o Egoism, [New York: Signet Books, 1964 Tara Smith, Moral Rights and Political Freedom Lanham, MD: Rowrnan and Littlefield, 1995 ; . pp. 112-116; Rasmussen-Den Uyl, Liberty and Nature, pp. 144-15. Tibor Machan, Human Rights and Human Liberties, pp. 213-222, Individuals and Their Rights, pp. 105-9; Generosity: Virtue in Civil Society, Washington, DC: Cato Institute, 19981, pp. 62-66. I should emphasize that these are different arguments to similar conclusions, not identical arguments to the same one. Further, on my classification, Rasmussen-Den Uyl and Machan are neo-AL theorists; Rand , Smith, and Locke are not. Note that in such cases, the result is not an augmentation of liberty. If, in a n emergency, I violate your liberties, your liberty is decreased-but my liberty is not increased In this case. I simply have no choice but to decrease your liberty to save [not my liberty but ; my life. The definition draws on Rand's; see 'The Ethics of Emergencies, " p. 54. Note that both differentiae are necessary conditions of something's being an emergency. Wars threaten life b u t aren't random; misfortune can be random, but rarely brings the danger of death. Neither wars nor misfortune a s such are emergencies. There are of course complicated borderline cases. fill of these would require separate analysis. Crises provide an interesting contrast to emergencies. As an example of a private crisis, Tibor Machan gives the example of one's car breaking down in the middle of a n unfamiliar neighborhood Indiuiduals a n d Their Rights, p. 108 ; . I agree with Machan's analysis of the case: this can't be an emergency because there's no significantly increased probability of death in the situation; the probability of death is probably lower if one isn't driving than if one is. Even someone on her way could not claim to be in "emergency" in the sense discussed in the to a n important job i n t text, however frustrating her circumstances. The stakes in such a case are simply not high enough to qualify a s an emergency. As examples of public crises, consider the nation's "health care crisis" or the "crisis of America's inner cities." These are ongoing, dysfunctional states of public affairs, not emergencies. Public crises, in this sense, are typically if not invariably due to long-term and intentional departures from neo-AL principles. Emergencies, by contrast, are temporary and unplanned events due to relatively random factors. The view I defend entails that if I somehow damage the homeowner's property while escaping from the dog e.g., break the fence, trample the bushes ; , it's morally justifiable for me to ignore the issue of damage during the attack, but obligatory for me to send the homeowner a check for the damage afterwards. The mere fact that I did the damage "during an emergency" doesn't absolve me from liability for the damage. After all, the emergent nature of the attack doesn't imply that I didn't violate the homeowner * rights; it only implies that I had to, because something more important was a t stake my body ; . But that "something" is no longer a t stake when I get safely home. It goes without saying that the situation i s fundamentally different if the homeowners own the dog! ; I thank Beau Bratton a n d Gregory Salmieri for useful discussions of this issue, and also thank "Rocky, " the German shepherd who made it all so vivid for me, for example, bentyl 10. In addition to the 2003 submissions, Merck has novel vaccine candidates, a diabetes drug and a drug for sleep disorders in the late-stage pipeline. The Company's preclinical and Phase I and II programs span a significant number of therapeutic categories and include work in the areas of diabetes, obesity, Alzheimer's disease, respiratory disease, coronary heart disease, rheumatoid arthritis and vaccines. New technologies give Merck the potential to move compound candidates into later stages for development faster than before. Merck supplements its internal research with an aggressive licensing and external alliance strategy focused on the entire spectrum of collaborations from early research to late-stage compounds. In 2003, the Company accelerated its efforts to fundamentally lower its cost structure through Company-wide initiatives. In October 2003, Merck announced the reduction of 4, 400 positions, which is expected to be completed in 2004. In addition, in the fourth quarter of 2003, the Company implemented a new distribution program for U.S. wholesalers to moderate the fluctuations in sales caused by wholesaler investment buying and improve efficiencies in the distribution of Merck pharmaceutical products. Each of Merck's major in-line franchises ranks either No. 1 or 2 its class in worldwide sales. This success has been driven largely by Merck's focus on developing novel medicines and demonstrating their value through proven health outcomes. Merck's strong financial profile enables the Company to fully fund research and development, aggressively focus on external alliances, support inline products and maximize upcoming launches while providing significant cash returns to shareholders. Earnings per common share assuming dilution from continuing operations for 2003 were $2.92, including the impact of the implementation of the new distribution program for U.S. wholesalers and restructuring costs related to position eliminations. Continuing operations excluded only the results from Medco Health. The Company anticipates full-year 2004 earnings per common share assuming dilution, including the effect of restructuring costs, of $3.11 to $3.17. 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Chronic pain patients need to be treated as outpatients within a continuum of treatment intensity. Outpatient chronic pain programs are available with services provided by a coordinated interdisciplinary team within the same facility formal ; or as coordinated by the authorized treating physician informal ; . Formal programs are able to provide coordinated, high intensity level of services and are recommended for most chronic pain patients who have received multiple therapies during acute management. Informal programs offer a lesser intensity of service and may be considered for patients who are currently employed, those who cannot attend all day programs, those with language barriers, or those living in areas not offering formal programs. Before treatment has been initiated, the patient, physician, and insurer should agree on treatment approach, methods, and goals. Generally the type of outpatient program needed will depend on the degree of impact the pain has had on the patient's medical, physical, psychological, social and or vocational functioning. When referring a patient for formal outpatient interdisciplinary pain rehabilitation or Work Hardening programs, the Division recommends the programs be Commission on Accreditation of Rehabilitation Facilities CARF ; eligible and or certified. CARF eligibility or certification ensures that programs meet specific care standards of design and efficacy. Inpatient Pain Rehabilitation Programs are rarely needed but may be necessary for patients with any of the following conditions: a ; High risk for medical instability; b ; Moderate to severe impairment of physical functional status; c ; Moderate to severe pain behaviors; d ; Moderate impairment of cognitive and or emotional status; e ; Dependence on medications from which he or she needs to be withdrawn; and f ; The need for 24hour supervised nursing. Outpatient interdisciplinary pain programs, whether formal or informal, should be comprised of the following dimensions: a. Communication: To ensure positive functional outcomes, communication between the patient, insurer and all professionals involved must be coordinated and consistent. Any exchange of information must be provided to all professionals, including the patient. Care decisions would be communicated to all. Documentation: Through documentation by all professionals involved and or discussions with the patient, it should be clear that functional goals are being actively pursued and measured on a regular basis to determine their achievement or need for modification. Treatment Modalities: Use of modalities may be necessary early in the process to facilitate compliance with and tolerance to therapeutic exercise, physical conditioning, and increasing functional activities. Active treatments should be emphasized over passive treatments. Active treatments should encourage selfcoping skills and management of pain, which can be continued independently at home or at work. Treatments that can foster a sense of dependency by the patient on the caregiver should be avoided. Treatment length should be decided based upon observed functional improvement. For a complete list of Active and Passive Therapies, refer to the Sections F.13 & 14, of this guideline. All treatment timeframes may be extended based upon the patient's positive functional improvement and terbutaline. 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HARMACEUTICAL COMPANIES ARE MASTERS of innothreatens important revenue vation--at least they say they BIG PHARMA'S streams within the company, it puts are. And with their business the company, rather than a competiNEW AGENDA FOR models based almost entirely tor, in control of the disruptive innoABOVE-AVERAGE vation. It can also lead to other on innovation, they ought to sources of revenue that more than GROWTH: be. Pharma should be one of compensate for the potential loss in the most innovative industries in the world, 1. Develop drugs for new customers existing business. Think of HP developing ink jet printing to directly combut this is not the case--new drug launches and new markets not yet addressed pete with its dominance of the laser by "good enough" products. "Me are down, even as R&D costs have risen printer market. too" drugs may reduce the risk of sharply. The industry suffers most because, on drug development, but new-market the whole, it aims at only one kind of innova4. Keep a critical eye on the products can be obtained by exterresources, processes, and priorities tion. When pharma sets out to make drugs nal acquisition or in-licensing. of the existing organization. If they "better, " it usually tries to make them more fail to support the innovations 2. Embrace customer-driven healtheffective. And while this sort of incremental needed, the firm must be ready to care by developing "good enough" innovation is key to developing new treatlow-cost solutions such as OTC drugs make the new initiative autonomous. For instance, HP set or simple treatment devices ; to comments or improving existing ones, it achieves up the DeskJet business in Boise, pete against more expensive or less little when the target market is already full of Idaho. ; Ensure that the manageconvenient prescription medications. ment team of the new initiative has satisfied customers. In a marketplace increasthe right skill set for the new initia3. Focus R&D on decreasing the ingly crowded with good products, compaprice and improving the convenience tive. The "right stuff" in the existing nies need disruptive innovations--new prodorganization may not ensure sucof solutions for problems that are ucts that are more convenient, simple, affordcess in a disruptive venture. being addressed in expensive, complicated ways. Even if this step able, and accessible than existing offerings-- to achieve new growth. The most successful companies of the past an insulin-injection pen that users found much more con50 years--from Apple to Wal-Mart--have devoted signifivenient than the common syringe. Even though Novo's pen cant resources to disruptive innovation. Typically, disrupoffered no improvement in terms of treatment efficacy and tive innovations either create new markets by bringing new sold for a price premium ; , the product took off rapidly features to non-consumers, or they trade off traditional because it was simple and easy to use. For Novo users, measures of performance in a way that appeals to existing "better" had nothing to do with Lilly's billion-dollar customers. Measured against established metrics, disrupimprovement in insulin purity. tive innovations may provide worse performance than Lilly tried to improve its product along well-established best-in-class solutions. But these innovations still appeal to measures of performance--we call this "sustaining innovacustomers on the basis of convenience, simplicity, price, or tion"--without considering whether the product was already accessibility--as long as they are good enough to meet the good enough for most customers. The company listened to customer's need. the input of leading physicians, who are often the doctors During the 1980s, Lilly, working with Genentech, spent who focus on the most challenging cases. The leap in perabout $1 billion to make a purer form of insulin than the formance may have been a technological breakthrough, but animal-derived product many diabetics injected every day. most patients were already satisfied and saw no reason to As the largest supplier of insulin, Lilly viewed improvement change to the more expensive Humulin. of the product's purity as a critical platform for revenue We have seen this tight focus on sustaining innovation growth. Key opinion leaders told the company repeatedly in more than 50 industries during 15 years of research. that this would reduce occasional side effects. Physicians Companies--from AT&T to Woolworth's--have stumand researchers, like Lilly's management, assumed that the bled when they failed to take a broad enough view. A commarket would embrace the purer insulin. However, the new pany's drive to innovate backfires when it is unwilling to formulation, called Humulin human insulin injection invest in innovations that depart from its well-established [rDNA origin] ; , was a major disappointment. Instead of business model. Insted of investing resources in disruptive switching to the "better" product, users were largely satisinnovation, companies let competitors seize these growth fied with the pork-derived insulin that they had used for opportunties. years. Most patients greeted the product with closed pocketbooks. A successful disruptive innovation was achieved at Disruptive Innovation about the same time by a then-small Danish company There's more to success than better efficacy. A 2003 study by called Novo. Novo--not yet Novo Nordisk--developed McKinsey located the most important drivers of drug-value and dicyclomine. Ually get it 12 to hours after taking the drug, and the symptom. 19. Supra note 2, at para 38 20. Supra note 2, at para 19. 21. Three weeks after Hamilton J.'s ruling, the Crown prosecutor announced that there would be no further legal proceedings against Dr. Morrison. He stated that the Crown would respect her decision and would not exercise its right to force Dr. Morrison to trial by way of a direct indictment. See The Globe and Mail, 12 Dec 1998, at A14. According to the local media there was overwhelming public support for Dr. Morrison; three months before the preliminary inquiry, it was reported that the Crown had received over 4, 000 cards and letters asking that the case be dropped. The Globe and Mail, 7 Nov. 1997, at A11. It may be that what explains the outcome of the case is that the courts and the Crown got the message and responded accordingly. 22. The Globe and Mail, 31 March 1998, at A3. 23. Ibid. 24. National Post, 1 April 1999, at A10. 25. Ibid. 26. Winnipeg Free Press, 12 Dec. 1998, at A14. 27. See N. MacDonald et al, `Opioid hyperexcitability: the application of alternate opioid therapy' 1993 ; 53 Pain 353-355. Dr. MacDonald is Professor of Palliative Medicine, Alberta Cancer Foundation, Department of Medicine, The University of Alberta. The authors present three cases of patients who experienced central nervous system adverse effects on high-dose hydromorphone Dilaudid ; . Two had received 200mg per hour and the third 65 mg per hour. Recall that Mr. Mills was on 200mg per hour at 1.30pm, which was increased to 250mg per hour at 1.50pm and finally to 500mg per hour at 2.25pm. 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