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 Patients should return to pre-treatment bowel function without requiring antidiarrhea medications for at least 24 hours before the next chemotherapy administration. A new cycle of therapy should not begin until the granulocyte count has recovered to 1500 mm3, and the platelet count has recovered to 100, 000 mm3, and treatment-related diarrhea is fully resolved. Treatment should be delayed 1 to 2 weeks to allow for recovery from treatment-related toxicities. If the patient has not recovered after a 2week delay, consideration should be given to discontinuing therapy During a Cycle of Therapy At the Start of Subsequent Cycles Toxicity of Therapyb NCI CTC Gradea Value ; No toxicity Maintain dose level Maintain dose level Neutropenia 3 1 1500 to 1999 mm ; Maintain dose level Maintain dose level 2 1000 to 1499 mm3 ; Maintain dose level 1 dose level 3 500 to 999 mm3 ; 1 dose level Omit dose until resolved to grade 2, then 1 dose level 3 4 500 mm ; 2 dose levels Omit dose until resolved to grade 2, then 2 dose levels Neutropenic fever Omit dose until resolved, then 2 dose levels Dose modifications for leukopenia or thrombocytopenia during a cycle of therapy and at the start of Other hematologic toxicities subsequent cycles of therapy are also based on NCI toxicity criteria and are the same as recommended for neutropenia above. Diarrhea 1 2-3 stools day pretxc ; Delay dose until resolved to baseline, then give same dose Maintain dose level 2 4-6 stools day pretx ; Maintain dose level Omit dose until resolved to baseline, then 1 dose level 3 7-9 stools day pretx ; 1 dose level Omit dose until resolved to baseline, then 1 dose level 4 10 stools day pretx ; 2 dose levels Omit dose until resolved to baseline, then 2 dose levels Other nonhematologic toxicitiesd 1 Maintain dose level Maintain dose level 2 Maintain dose level Omit dose until resolved to grade 1, then 1 dose level 3 1 dose level Omit dose until resolved to grade 2, then 1 dose level 4 2 dose levels Omit dose until resolved to grade 2, then 2 dose levels For mucositis stomatitis decrease only 5-FU, not CAMPTOSAR For mucositis stomatitis decrease only 5-FU, not CAMPTOSAR.
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Sa1.117 - Regulation of Autoimmune Arthritis by the HomoloCryptic gous Dominant Self and Cr yptic Mycobacterial Hsp65 Sa1.112 - Identification of Genes Participating in Suppres- Epitopes. sion of Murine SLE by CD8 + Ti Cells. M. Durai, 1 H. R. Kim, 1 Y. Mia, 1 E. Kim, 1 K. D. Moudgil.1 1MiR. P. Singh, F. M. Ebling, D. Elashoff, D. V. Sven, C. Zamber, D. crobiology and Immunology, University of Maryland School of Patel, A. L. Cava, B. H. Hahn. 1Division of Rheumatology Medicine, Baltimore, MD, USA. Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Dept. of Biosatstics, Haematology Onccology, Sa1.118 - Both Chlordecone and Estrogen Enhance the GerDavid Geffen School of Medicine at UCLA, Los Angeles, CA, minal Center B Cell Reaction and Reduce the Splenic B Cell USA; 3Research Department, Genome Explorations Inc., MemApoptosis in Ovariectomized NZB x NZW ; F1 Mice. phis, TN, USA. F. Wang, 1, 2 S. M. Roberts, 1, 3 E. S. Sobel.2 1Department of Pharmacology and Therapeutics, University of Florida College of Sa1.113 - Impact of Gender on Immune Nephritis. Medicine, Gainesville, FL, USA; 2Department of Medicine, UniT. Henry, Y. Fu, J. Zhou, C. Mohan. 1Internal Medicine-Rheuversity of Florida College of Medicine, Gainesville, FL, USA; matology, University of Texas Southwestern Medical Center, 3 Department of Physiological Sciences, University of Florida Dallas, TX, USA. College of Veterinary Medicine, Gainesville, FL, USA. Sa1.114 - Use of Gene-Expression Profiling in Labial Salivary To vary Glands Using cDNA Microarrays To Identify New PathoPrimary Sjgren's genic Pathways in Primar y Sjgren's Syndrome. Jacques-Eric Gotttenberg, 1 Carlo Lucchesi, 2 Nicolas Cagnard, 2 Franck Letourneur, 2 Sylvie Mistou, 2 Jean Sibilia, 3 Gilles Chiocchia, 2 Xavier Mariette.1 1Rheumatology, INSERM E 109, Bicetre Hospital, Le Kremlin Bicetre, France; 2Immunology, Institut Cochin, Paris, France; 3Rheumatology, Strasbourg Hospital, Strasbourg, France. Sa1.119 - IL10 Promoter Polymorphisms in Mexican Patients with Spondyloarthropathies. G. Vargas-Alarcon, 1 J.M. Rodriguez-Perez, 1 G. HernandezPacheco, 1 J. Londono, 2 C. Pacheco-Tena, 3 J. Granados, 2 R. Burgos-Vargas.3 1Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico; 2Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico; 3Rheumatology, Hospital General de Mexico, Mexico City, Mexico and diltiazem, because adalat.

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